CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

• Published in: Journal of medical biochemistry 2016-01, Vol.35 (1), p.34-42
• Main Authors: Hashim, Amel A., Ali, Sahar A., Emara, Ibrahim A., El-Hefnawy, Mohamed H.
• Format: Article
• Language: English
• Subjects: adiponectin; adiponektin; bone biochemical markers; clinical; CTX; klinički; koštani bio- hemijski markeri; T1DM
• ISSN: 1452-8266; 1452-8258; 1452-8266
• DOI: 10.1515/jomb-2015-0011

Background:In this study, we investigated the relationship of adiponectin with bone marker changes in Egyptian children and adolescents with T1DM and the effect of disease duration on these markers, as well as the possible correlations between adiponectin and bone markers in these patients. Methods: Sixty Egyptian children and adolescent patients with T1DM were studied. Serum adiponectin and collagen breakdown products (cross-linked C-terminal telopeptide of collagen type l »CTX«) were measured and compared to the results of 20 age-matched healthy controls. Results: After adjustment for age, BMI, Tanner stage and gender; (total) adiponectin was significantly higher in all T1DM patients. Serum level of CTX and 25(OH)D showed a marked decrease in diabetics with disease duration > 5 years. Serum level of (total) calcium and inorganic phosphorus (Pi) did not show significant difference from control. CTX was inversely correlated to FBG and T1DM duration. Pi was inversely, while 25(OH)D was directly correlated to FBG. Total calcium showed an inverse correlation with HbA1c. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM. Conclusions: Adiponectin showed no correlation with either CTX or bone homeostatic indices. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM. We recommend further investigation of adiponectin isoforms in a population-based study, to establish a good age- and sexrelated reference. Uvod: U ovoj studiji istraživali smo odnos između adiponektina i markera koštanih promena kod egipatske dece i ado­lescenata sa T1DM, uticaj trajanja bolesti na ove markere, kao i potencijalne korelacije između adiponektina i ko­štanih markera kod ovih pacijenata. Metode: Proučavano je šezdesetoro dece i adolescenata egipatske nacionalnosti sa T1DM. Mereni su serumski adi- ponektin i produkti razgradnje kolagena (cross-linked C-terminalni telopeptid kolagena tip I, CTX) i upoređeni sa rezultatima 20 zdravih kontrolnih subjekata odgovarajućeg uzrasta. Rezultati: Posle prifagođavanja za uzrast, indeks telesne mase, Tanerovu skalu i pol; (ukupni) adiponektin bio je značajno viši kod svih pacijenata sa T1 DM. CTX je pokazao izrazit pad kod dijabetičara sa trajanjem bolesti > 5 godina. Serumski nivo 25(OH)D, (ukupni) kalcijum i neorganski fosfor (Pj) nisu se značajno razlikovali u odnosu na kon­trolu. CTX je bio u inverznoj korelaciji sa FBG i trajanjem T1DM. P| je bio u inverznoj, a 25(OH)D u direktnoj ko­relaciji sa FBG. Ukupni kalcijum bio je