Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze

Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis. Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from Janua...

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Published in:Journal of medical biochemistry 2016-01, Vol.35 (1), p.63-68
Main Authors: Acimovic, Milena, Vidakovic, Snezana, Milic, Natasa, Jeremic, Katarina, Markovic, Milos, Milosevic-Djeric, Ana, Lazovic-Radonjic, Gordana
Format: Article
Language:English
Subjects:
CA125
Endometriosis
endometrioza
lapa - roscopy
lapa- roskopija
survivin
transvaginal ultrasound
transvaginalni ultrazvuk
VEGE CA125
VEGF
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Summary:Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis. Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher’s, Student’s t-test or the Mann - Whitney test. Results: There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p
ISSN:1452-8266
1452-8258
1452-8266
DOI:10.1515/jomb-2015-0005