Study of Protein Haptenation By Biotinylated Clavulanic Acid: Usefulness in Studies on Allergy Towards Betalactams

Lately, immediate allergic reactions to CLV have been reported in 30% of patients allergic to Amoxicillin-CLV. Since protein haptenation with betalactams is known to be necessary to activate the immune system, the objective was to study haptenation and develop tools to identify CLV target proteins.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB46-AB46
Main Authors: Martin-Serrano, Angela, Barbero, Nekane, PhD, Ariza, Adriana, PhD, Fernandez, Tahia D., PhD, Perez-Inestrosa, Ezequiel, PhD, Salas, Maria, MD, PhD, Mayorga, Cristobalina, PhD, Perez-Sala, Dolores, PhD, Torres, Maria J., MD, PhD, Montañez, Maria I., PhD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Genes
Immune system
Proteins
Online Access:Get full text
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Description
Summary:Lately, immediate allergic reactions to CLV have been reported in 30% of patients allergic to Amoxicillin-CLV. Since protein haptenation with betalactams is known to be necessary to activate the immune system, the objective was to study haptenation and develop tools to identify CLV target proteins.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.204