Mir-4443, a Possible Participant in Mast Cell Activation By T Cell-Derived Microvesicles

Conclusions These results support a scenario by which T cell-derived MVs may act as intercellular carriers of functional miR 4443 that may exert heterotypic regulation of PTPRJ gene expression in mast cells leading to their activation in the context of T cell-mediated inflammatory processes.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB169-AB169
Main Authors: Mekori, Yoseph A, Shefler, Irit
Format: Article
Language:English
Subjects:
Allergy and Immunology
Gene expression
Histamine
Lymphocytes
MicroRNAs
Online Access:Get full text
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Description
Summary:Conclusions These results support a scenario by which T cell-derived MVs may act as intercellular carriers of functional miR 4443 that may exert heterotypic regulation of PTPRJ gene expression in mast cells leading to their activation in the context of T cell-mediated inflammatory processes.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.556