TGF-[beta] pathway activation primes naïve lymphocytes to support atopic phenotypes in humans

Conclusions TGF-β can promote IL-4/IL4Rα/GATA3 axis activation in human T cells in vitro, and enhanced lymphocyte-intrinsic TGF-β activity is associated with elevated Th2 cytokine-expressing memory cells and serum IgE in humans.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB93
Main Authors: Lyons, Jonathan, Liu, Yihui, Ma, Chi A, Yu, Xiaomin, O'Connell, Michael, Hughes, Jason, McElwee, Joshua, Stone, Kelly D, Frischmeyer-Guerrerio, Pamela A, Holland, Steven M, Freeman, Alexandra F, Milner, Joshua D
Format: Article
Language:English
Subjects:
Kinases
Lymphocytes
Mutation
Online Access:Get full text
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Description
Summary:Conclusions TGF-β can promote IL-4/IL4Rα/GATA3 axis activation in human T cells in vitro, and enhanced lymphocyte-intrinsic TGF-β activity is associated with elevated Th2 cytokine-expressing memory cells and serum IgE in humans.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.254