Role of Endogenous Protease Inhibitor in Airway Epithelial Cells in the Pathogenesis of Eoshinophilic Chronic Rhinosinusitis

[...]allergens-induced secretion of IL-25, IL-33 and TSLP were significantly increased by infecting NHBE cells with small interfering RNA for SPINK5 or Cystatin A. Conclusions These results indicate that cystatin A and SPINK5 play an important role in protecting airway epithelium from exogenous prot...

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Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB63-AB63
Main Authors: Kouzaki, Hideaki, Tojima, Ichiro, Kato, Tomohisa, Matsumoto, Koji, Shimizu, Shino, Shimizu, Takeshi, Kita, Hirohito, MD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Pathogenesis
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Summary:[...]allergens-induced secretion of IL-25, IL-33 and TSLP were significantly increased by infecting NHBE cells with small interfering RNA for SPINK5 or Cystatin A. Conclusions These results indicate that cystatin A and SPINK5 play an important role in protecting airway epithelium from exogenous proteases, and that the decreased expression of EPIs may be involved in the pathogenesis of intractable eosinophilic CRS.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.157