Inhibition of Vascular Endothelial Abl1 Signaling Protects Against Food-Induced Anaphylaxis in Mice

Methods We employed BALB/c wild-type (WT), intestinal IL-9Tg and VE-specific Abl1 kinase-deficient (Cdh5CreAbl1fl/fl) mice and pharmacologic inhibitors (Imatinib) and models of anaphylaxis to determine the requirement of Abl1 kinase in IgE-mediated reactions.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB277-AB277
Main Authors: Hogan, Simon P., PhD, Waggoner, Lisa, MS, Wu, David, PhD, Yamani, Amnah N., MS
Format: Article
Language:English
Subjects:
Allergy and Immunology
Rodents
Online Access:Get full text
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Description
Summary:Methods We employed BALB/c wild-type (WT), intestinal IL-9Tg and VE-specific Abl1 kinase-deficient (Cdh5CreAbl1fl/fl) mice and pharmacologic inhibitors (Imatinib) and models of anaphylaxis to determine the requirement of Abl1 kinase in IgE-mediated reactions.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.890