Effects of manganese on potassium outflow from erythrocytes and on respiration of rat liver mitochondria

In this work, effects of manganese on respiration of rat liver mitochondria and the rate of K + outflow from rat erythrocytes are studied in a broad range of concentrations. It is shown that manganese ions at low concentrations (1 × 10 –7 –3 × 10 –5 М) inhibit K + outflow from rat erythrocytes; this...

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Published in:Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2017, Vol.11 (1), p.77-81
Main Authors: Goncharenko, M. S., Tkachenko, A. I., Khmil, N. V., Murzaeva, S. M., Korobeynikova, M. O., Lezhnev, E. I., Kolomytkin, O. V., Mironova, G. D.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Erythrocytes
Life Sciences
Mitochondria
Potassium
Respiration
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Summary:In this work, effects of manganese on respiration of rat liver mitochondria and the rate of K + outflow from rat erythrocytes are studied in a broad range of concentrations. It is shown that manganese ions at low concentrations (1 × 10 –7 –3 × 10 –5 М) inhibit K + outflow from rat erythrocytes; this can be used to prevent their lysis. At high concentrations (1 × 10 –4 –1 × 10 –3 M), manganese activates K + outflow from the erythrocytes but inhibits the valinomycin-induced outflow of the ion from the erythrocytes. This fact is an indication of manganese influence on physicochemical properties of membranes. At low concentrations manganese does not affect parameters of respiration and oxidative phosphorylation of rat liver mitochondria, while at high concentrations it exerts acceleration of the mitochondrial respiration, i.e., uncouples respiration from phosphorilation and, hence, inhibits ATP synthesis.
ISSN:1990-7478
1990-7494
DOI:10.1134/S1990747816040036