Three-Dimensional Cd(II) Coordination Compound with [alpha]-Po Topology Framework

Nicotinic acetylcholine receptors (nAChRs) are a highly conserved gene family that form pentameric receptors involved in fast excitatory synaptic neurotransmission. The specific roles individual nAChR subunits perform in Drosophila melanogaster and other insects are relatively uncharacterized. Of th...

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Bibliographic Details
Published in:Genetics (Austin) 2017-01, Vol.205 (1), p.263
Main Authors: Somers, Jason, Luong, Hang Ngoc Bao, Mitchell, Judith, Batterham, Philip, Perry, Trent
Format: Article
Language:English
Subjects:
Behavior
Bioassays
Costs
Genes
Insects
Ligands
Mutation
Nervous system
Pesticides
Sleep
Online Access:Get full text
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Summary:Nicotinic acetylcholine receptors (nAChRs) are a highly conserved gene family that form pentameric receptors involved in fast excitatory synaptic neurotransmission. The specific roles individual nAChR subunits perform in Drosophila melanogaster and other insects are relatively uncharacterized. Of the 10 D. melanogaster nAChR subunits, only three have described roles in behavioral pathways; D[alpha]3 and D[alpha]4 in sleep, and D[alpha]7 in the escape response. Other subunits have been associated with insecticide resistance. While acetylcholine signaling had previously been linked with mating behavior and reproduction in D. melanogaster, no specific nAChR subunit had been directly subunits, only three have described roles in behavioral pathways; D[alpha]3 and D[alpha]4 in sleep, and D[alpha]7 in the escape response. Other subunits have been associated with associated with neonicotinoid resistance.
ISSN:0016-6731
1943-2631
DOI:10.1534/genetics.116.195750