Cover Picture: Highly Conformationally Restricted Cyclopropane Tethers with Three‐Dimensional Structural Diversity Drastically Enhance the Cell Permeability of Cyclic Peptides (Chem. Eur. J. 13/2017)

Cyclopropane tethers with three‐dimensional structural diversity are able to remarkably change the conformation and physicochemical properties of cyclic peptides due to the characteristic steric feature of cyclopropane. In particular, the introduction of a cyclopropane tether (CPT), cis‐NfCf fixed t...

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Bibliographic Details
Published in:Chemistry : a European journal 2017-03, Vol.23 (13), p.2970-2970
Main Authors: Matsui, Kouhei, Kido, Yasuto, Watari, Ryosuke, Kashima, Yousuke, Yoshida, Yutaka, Shuto, Satoshi
Format: Article
Language:English
Subjects:
cell permeability
Chemistry
conformation analysis
cyclic peptides
cyclopropane
NMR spectroscopy
Permeability
Online Access:Get full text
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Summary:Cyclopropane tethers with three‐dimensional structural diversity are able to remarkably change the conformation and physicochemical properties of cyclic peptides due to the characteristic steric feature of cyclopropane. In particular, the introduction of a cyclopropane tether (CPT), cis‐NfCf fixed the conformation suitable for passive transport and dramatically improved the cell permeability of a model cyclic peptide. More information can be found in the Full Paper by S. Shuto et al. on page 3034 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201605863