Alcohol intoxication and advanced age impair the pulmonary inflammatory response to infection
Aged mice (18-20 months) given an intratracheal Pseudomonas aeruginosa infection had reduced survival, increased circulating granulocytes, and defective neutrophil directional migration, when compared to young (2-4 months) infected mice. Since intoxication and advanced age independently reduce host...
Saved in:
Published in: | Alcohol (Fayetteville, N.Y.) N.Y.), 2017-03, Vol.59, p.72-72 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Aged mice (18-20 months) given an intratracheal Pseudomonas aeruginosa infection had reduced survival, increased circulating granulocytes, and defective neutrophil directional migration, when compared to young (2-4 months) infected mice. Since intoxication and advanced age independently reduce host immunity, we addressed whether alcohol intoxication alters the innate immune response to infection in aged mice. |
---|---|
ISSN: | 0741-8329 1873-6823 |
DOI: | 10.1016/j.alcohol.2016.10.022 |