Alcohol intoxication and advanced age impair the pulmonary inflammatory response to infection

Aged mice (18-20 months) given an intratracheal Pseudomonas aeruginosa infection had reduced survival, increased circulating granulocytes, and defective neutrophil directional migration, when compared to young (2-4 months) infected mice. Since intoxication and advanced age independently reduce host...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2017-03, Vol.59, p.72-72
Main Authors: Curtis, B.J, Albright, J.M, Boe, D.M, Kovacs, E.J
Format: Article
Language:English
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Summary:Aged mice (18-20 months) given an intratracheal Pseudomonas aeruginosa infection had reduced survival, increased circulating granulocytes, and defective neutrophil directional migration, when compared to young (2-4 months) infected mice. Since intoxication and advanced age independently reduce host immunity, we addressed whether alcohol intoxication alters the innate immune response to infection in aged mice.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2016.10.022