Cover Picture: Total Synthesis of Leupyrrins A1 and B1, Highly Potent Antifungal Agents from the Myxobacterium Sorangium cellulosum (Chem. Eur. J. 14/2017)

The total syntheses of leupyrrins A1 and B1, antifungal agents from Sorangium cellulosum, are presented. We associate the building blocks of leupyrrins, being natural products, with the four natural elements—fire, water, air, and earth. These four elements also had a key significance in the synthesi...

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Bibliographic Details
Published in:Chemistry : a European journal 2017-03, Vol.23 (14), p.3222-3222
Main Authors: Thiede, Sebastian, Wosniok, Paul R., Herkommer, Daniel, Debnar, Thomas, Tian, Maoqun, Wang, Tongtong, Schrempp, Michael, Menche, Dirk
Format: Article
Language:English
Subjects:
antifungal agent
Chemistry
domino reactions
leupyrrin
natural products
total synthesis
Online Access:Get full text
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Summary:The total syntheses of leupyrrins A1 and B1, antifungal agents from Sorangium cellulosum, are presented. We associate the building blocks of leupyrrins, being natural products, with the four natural elements—fire, water, air, and earth. These four elements also had a key significance in the synthesis: heating (fire) for the synthesis of the pyrrole fragment, an enzyme‐catalyzed reaction (water) for the butyrolactone, a hydrogenation (air) for the diacid, and the metal Zr (earth) for the diyne. More information can be found in the Full Paper by D. Menche et al. on page 3300 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201605970