Comparative Analysis of the Antineoplastic Activity of C^sub 60^ Fullerene with 5-Fluorouracil and Pyrrole Derivative In Vivo

The antitumor activity of pristine C60 fullerene aqueous solution (C60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced...

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Bibliographic Details
Published in:Nanoscale research letters 2017-01, Vol.12 (1), p.1
Main Authors: Lynchak, O V, Prylutskyy, Yu I, Rybalchenko, V K, Kyzyma, O A, Soloviov, D, Kostjukov, V V, Evstigneev, M P, Ritter, U, Scharff, P
Format: Article
Language:English
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Summary:The antitumor activity of pristine C60 fullerene aqueous solution (C60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measured, and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of C60FAS and MI-1. Because these drugs have different mechanisms of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.
ISSN:1931-7573
1556-276X
DOI:10.1186/s11671-016-1775-0