MAST CELL-DEPENDENT CONVERSION OF SIDEROPHAGES INTO FOAM CELLS IS A HALLMARK OF EARLY FAT INFILTRATION IN HEMORRHAGIC MYOCARDIAL INFARCTIONS

Histopathological studies demonstrated both iron and fat deposits within all chronic MIs. [...]sparse fat deposits within scars were exclusively colocalized with iron deposits, mast cells, newly recruited MAC387+ macrophages, oxidized phospholipid products (EO6+ regions), CD36+ foam cells, iron indu...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2017-03, Vol.69 (11), p.756-756
Main Authors: Cokic, Ivan, Kali, Avinash, Yang, Hsin-Jung, Tang, Richard, Francis, Joseph, Dharmakumar, Rohan
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Heart attacks
Histamine
Internal Medicine
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Summary:Histopathological studies demonstrated both iron and fat deposits within all chronic MIs. [...]sparse fat deposits within scars were exclusively colocalized with iron deposits, mast cells, newly recruited MAC387+ macrophages, oxidized phospholipid products (EO6+ regions), CD36+ foam cells, iron induced CD163+ macrophages, as well as the proinflammatory markers (IL-1β, TNF-α and MMP9) (Figure 1C-L).
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(17)34145-1