PRO-INFLAMMATORY INTERLEUKIN-1 GENOTYPES AFFECT THE ASSOCIATION OF C-REACTIVE PROTEIN FOR ANGIOGRAPHICALLY DETERMINEDCORONARY ARTERY DISEASE AND CARDIOVASCULAR EVENTS

Background: Pro-inflammatory Interleukin-1 (IL-1) genotypes have been related to an increased risk of angiographic coronary artery disease (CAD) that is mediated by inflammation markers such as lipoprotein(a)[Lp(a)] and oxidized phospholipids(OxPL-apoB) in non-diabetic patients. Since the IL-1 genot...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2017-03, Vol.69 (11), p.193-193
Main Authors: Bechlioulis, Aris, Naka, Katerina K, Doucette-Stamm, Lynn, Wilkins, Leon, Marini, Aikaterini, Giannitsi, Sophia, Rogus, John, Kornman, Kenneth, Witztum, Joseph L, Tsimikas, Sotirios, Michalis, Lampros K
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Cardiovascular disease
Coronary vessels
Cytokines
Diabetes
Genotype & phenotype
Health risk assessment
Internal Medicine
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Summary:Background: Pro-inflammatory Interleukin-1 (IL-1) genotypes have been related to an increased risk of angiographic coronary artery disease (CAD) that is mediated by inflammation markers such as lipoprotein(a)[Lp(a)] and oxidized phospholipids(OxPL-apoB) in non-diabetic patients. Since the IL-1 genotype has been associated with greater expression of IL-1β and higher blood levels of C-reactive protein (hsCRP), we investigated whether IL-1 genotype status may also affect the relationship of hsCRP with angiographic CAD and cardiovascular events.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(17)33582-9