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Inclusion of BLIMP-1^sup +^ effector regulatory T cells improves the Immunoscore in a cohort of New Zealand colorectal cancer patients: a pilot study

Analysis of tumour-infiltrating T cells in colorectal cancer can predict disease-free survival. The Immunoscore, obtained by quantifying tumour-infiltrating CD3+ and CD8+ T cells, may improve current staging. Effector regulatory T cells are a potently suppressive subset in mice and, while present in...

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Bibliographic Details
Published in:Cancer immunology, immunotherapy immunotherapy, 2017-04, Vol.66 (4), p.515
Main Authors: Ward-hartstonge, Kirsten A, Mccall, John L, Mcculloch, Timothy R, Kamps, Ann-kristin, Girardin, Adam, Cretney, Erika, Munro, Fran M, Kemp, Roslyn A
Format: Article
Language:English
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Summary:Analysis of tumour-infiltrating T cells in colorectal cancer can predict disease-free survival. The Immunoscore, obtained by quantifying tumour-infiltrating CD3+ and CD8+ T cells, may improve current staging. Effector regulatory T cells are a potently suppressive subset in mice and, while present in human colorectal cancer, their role in patient outcome is unknown. Immunofluorescence was used to analyse immune cell infiltrates in patients with early (stage II) colorectal cancer with (n=13) and without (n=19) recurrent disease. CD3 and CD8 were used for the Immunoscore; FOXP3, BLIMP-1 and CD3 to identify effector regulatory T cells. Patients with high Immunoscores had increased disease-free survival compared to patients with low Immunoscores (Log-rank test p
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-016-1951-1