N,N′‐Dialkyl‐4‐Aryl‐3,4‐Dihydropyrimidinones and Thiones: Ceric Ammonium Nitrate Catalyzed Synthesis and Molecular Structure Determination by X‐ray Crystallography

This work presents a microwave assisted solvent‐free synthesis of N,N′‐dialkyl‐4‐aryl‐3,4‐dihydropyrimidinones/thiones in the presence of Ceric Ammonium Nitrate (CAN) via direct condensation of aromatic aldehydes, β‐keto ester, and N,N′‐dialkylurea/thiourea. The highlights of the methodology adopted...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2017-03, Vol.54 (2), p.1486-1491
Main Authors: Kathing, Chingrishon, Kumar, Sushil, Tumtin, Shokip, Singh, Nongthombam Geetmani, Rani, Jims World Star, Nongrum, Ridaphun, Nongkhlaw, Rishanlang
Format: Article
Language:English
Subjects:
Diffraction
X-rays
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Summary:This work presents a microwave assisted solvent‐free synthesis of N,N′‐dialkyl‐4‐aryl‐3,4‐dihydropyrimidinones/thiones in the presence of Ceric Ammonium Nitrate (CAN) via direct condensation of aromatic aldehydes, β‐keto ester, and N,N′‐dialkylurea/thiourea. The highlights of the methodology adopted are (i) facile condensation of the reactants into product without any side‐products, and (ii) short reaction time with high yield and good purity. All the compounds synthesized were characterized and established by spectroscopic techniques such as FTIR, 1H NMR, 13C NMR, and Mass. The structure of the compound is further corroborated by single crystal X‐ray diffraction analysis.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2735