Design and Synthesis of 2,5‐Disubstituted‐1,3,4‐Oxadiazole Hybrids Bearing Pyridine and 1,2,3‐Triazole Pharmacophores

A novel series of 2,5‐disubstituted‐1,3,4‐oxadiazoles decorated with two biodynamic moieties pyridine and 1,2,3‐triazole have been successfully synthesized in good yields under mild reaction conditions. The synthesized compounds are valuable for biological activity exploration since three biodynamic...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2017-03, Vol.54 (2), p.1042-1047
Main Authors: Kaushik, Reena, Kushwaha, Khushbu, Chand, Mahesh, Vashist, Monika, Jain, Subhash C.
Format: Article
Language:English
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Summary:A novel series of 2,5‐disubstituted‐1,3,4‐oxadiazoles decorated with two biodynamic moieties pyridine and 1,2,3‐triazole have been successfully synthesized in good yields under mild reaction conditions. The synthesized compounds are valuable for biological activity exploration since three biodynamic moieties are covalently linked together in a single molecular framework. All the synthesized compounds were fully characterized by their detailed spectral studies IR, 1HNMR, 13C NMR and Mass.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2672