Synthesis of 5-(pyrazol-1-yl)-1,2,3-thiadiazoles

A method is proposed for the synthesis of ethyl 5-(3-aryl-4-formyl-1 H -pyrazol-1-yl)-1,2,3-thiadiazole-4-carboxylates by a reaction of acetophenone (4-ethoxycarbonyl-1,2,3-thiadiazol-5-yl)hydrazones with a Vilsmeier–Haack complex. The obtained heterocyclic assemblies provide interesting substrates...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2017-02, Vol.53 (2), p.236-238
Main Authors: Vysokova, Olga A., Kalinina, Tatiana A., Tokareva, Marina A., Pospelova, Tatiana A., Glukhareva, Tatiana V., Morzherin, Yuri Yu
Format: Article
Language:English
Subjects:
Acetophenone
Aromatic compounds
Biological activity
Carboxylates
Chemical synthesis
Chemistry
Chemistry and Materials Science
Hydrazones
Organic Chemistry
Pharmacy
Short Communication
Substrates
Thiadiazoles
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Summary:A method is proposed for the synthesis of ethyl 5-(3-aryl-4-formyl-1 H -pyrazol-1-yl)-1,2,3-thiadiazole-4-carboxylates by a reaction of acetophenone (4-ethoxycarbonyl-1,2,3-thiadiazol-5-yl)hydrazones with a Vilsmeier–Haack complex. The obtained heterocyclic assemblies provide interesting substrates for further modification and study of biological activity.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-017-2045-5