Chelator-free radiolabeling of dextran with 68Ga for PET studies

The possibility of 68 Ga-dextran complex formation was analyzed in an HEPES-buffered (pH = 4.5) as well as in an alkaline (pH = 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml −1 dextran solution (10 min, 90 °C...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2017-03, Vol.311 (3), p.1811-1817
Main Authors: Gholipour, Nazila, Akhlaghi, Mehdi, Kheirabadi, Amin Mokhtari, Beiki, Davood, Geramifar, Parham, Yousefnia, Hassan, Mazidi, Mohammad
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Complex formation
Dextrans
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Radiolabelling
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Summary:The possibility of 68 Ga-dextran complex formation was analyzed in an HEPES-buffered (pH = 4.5) as well as in an alkaline (pH = 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml −1 dextran solution (10 min, 90 °C). 68 Ga-dextran was stable 88, 71 and 86% after 2 h at storage and toward cysteine solution and human serum, respectively. The highest ROI derived %ID g −1 was found within the lungs, followed by the blood, liver, and bladder. Furthermore, a significant uptake was observed in the cartilage tissue. 68 Ga-dextran excreted more by the urinary and less by the biliary pathways.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-016-5164-z