Atomic force microscopy of swelling and hardening of intact erythrocytes fixed on substrate

Peak force measurements with the aid of atomic force microscopy are used to quantitatively map nanomechanical properties of intact erythrocytes of rats under conditions that are close to physiological conditions. Erythrocytes that are immobilized on the substrate preliminary processed using poly-L-l...

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Bibliographic Details
Published in:Technical physics 2017-02, Vol.62 (2), p.310-313
Main Authors: Khalisov, M. M., Timoshchuk, K. I., Ankudinov, A. V., Timoshenko, T. E.
Format: Article
Language:English
Subjects:
Analysis
Atomic force microscopy
Biomedical Physics
Classical and Continuum Physics
Erythrocytes
Hardening
Lysine
Microscopy
Physics
Physics and Astronomy
Physiological aspects
Rats
Transformations
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Summary:Peak force measurements with the aid of atomic force microscopy are used to quantitatively map nanomechanical properties of intact erythrocytes of rats under conditions that are close to physiological conditions. Erythrocytes that are immobilized on the substrate preliminary processed using poly-L-lysine predominantly exhibit plane shape. However, cells may also exhibit stepwise transformation to semispherical objects with an increase in volume and hardening. Possible reasons for such transformations are discussed.
ISSN:1063-7842
1090-6525
DOI:10.1134/S1063784217020116