Formaldehyde induces DNA strand breaks on spermatozoa and lymphocytes of Wistar rats

Formaldehyde (FA) interacts with biological molecules such as DNA and it induces DNA-protein cross-links (DPCs), oxidative stress, reactive oxygen species (ROS), methylation, chromosomal damage, fragmentation, and adducts of DNA, which are considered the most important genotoxic effects caused by ex...

Full description

Saved in:
Bibliographic Details
Published in:Cytology and genetics 2017, Vol.51 (1), p.65-73
Main Authors: Jiménez-Villarreal, J., Betancourt-Martínez, N. D., Carranza-Rosales, P., Viveros-Valdez, E., Guzmán-Delgado, N. E., López-Márquez, F. C., Martíneza, Javier Morán
Format: Article
Language:English
Subjects:
Adducts
Biomedical and Life Sciences
Biomedicine
Deoxyribonucleic acid
DNA
DNA adducts
DNA damage
DNA fragmentation
DNA methylation
Formaldehyde
Genotoxicity
Human Genetics
Lymphocytes
Oxidative stress
Reactive oxygen species
Rodents
Sperm
Tubules
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Formaldehyde (FA) interacts with biological molecules such as DNA and it induces DNA-protein cross-links (DPCs), oxidative stress, reactive oxygen species (ROS), methylation, chromosomal damage, fragmentation, and adducts of DNA, which are considered the most important genotoxic effects caused by exposure to FA. The purpose of this study was to evaluate the percentage of DNA fragmentation on lymphocytes and spermatozoa from Wistar rats exposed to different doses of FA. The results about the percentage of fragmentation of DNA in lymphocytes and spermatozoa, were statistical different from controlled group versus treated groups respectively to ( p < 0.05). Pathological changes were observed in the seminiferous tubules, especially in rats exposed to 30 mg/kg of FA. This study provided additional evidence supporting that FA induces DNA strand breaks in both cells and therefore genotoxic damage in Wistar rats.
ISSN:0095-4527
1934-9440
DOI:10.3103/S0095452717010078