A comparison of electrospray tandem mass spectra of some sialic acid derivatives: Ion trap and high resolution QqToF mass spectrometers

Using O -acetyl- N -acyl derivatives of O -methyl sialoside methyl esters, it was shown that an ion trap and a hybrid analyzer (linear quadrupole–time-of-flight analyzer, reflectron) give comparable, though not identical secondary mass spectra for the [M + Na] + and [M + K] + ions. A parallel use of...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2016-12, Vol.71 (14), p.1392-1396
Main Authors: Chizhov, A. O., Shpirt, A. M., Savel’eva, N. Y., Kononov, L. O.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemical properties
Chemistry
Chemistry and Materials Science
Comparative analysis
Esters
Fragmentation
Glycoconjugates
Mass spectra
Mass spectrometers
Mass spectroscopy
Organic acids
Quadrupoles
Sialic acids
Spectrometers
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Summary:Using O -acetyl- N -acyl derivatives of O -methyl sialoside methyl esters, it was shown that an ion trap and a hybrid analyzer (linear quadrupole–time-of-flight analyzer, reflectron) give comparable, though not identical secondary mass spectra for the [M + Na] + and [M + K] + ions. A parallel use of an ion trap and a hybrid QqToF instrument gives information about the fragmentation pathways of ions of sialic acid derivatives under collisional activation. In this case, the sequence of fragmentation may be established using an ion trap, whereas a QqToF instrument offers a possibility of revealing the elemental composition of fragment ions quickly and unequivocally.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934816140045