Comprehensive assessment of the hemostasis system in the participants of the Mars-500 experiment

Hemostasis has been studied in the course of long-term (520 days) isolation in hermetic chamber. Measured parameters included activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin time (ТT); concentrations of fibrinogen (FBG), plasminogen (PG), Willebrand facto...

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Bibliographic Details
Published in:Human physiology 2016-12, Vol.42 (7), p.782-787
Main Authors: Kuzichkin, D. S., Markin, A. A., Vorontsov, A. L., Morukov, B. V., Zhuravleva, O. A., Zabolotskaya, I. V., Vostrikova, L. V.
Format: Article
Language:English
Subjects:
Antithrombin
Biomedical and Life Sciences
Biomedicine
Blood coagulation
Blood levels
Coagulation
Experimental and Theoretical Studies
Fibrinogen
Hemostasis
Human Physiology
Life Sciences
t-Plasminogen activator
Thrombin
Thrombomodulin
Thromboplastin
Tissue factor
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Summary:Hemostasis has been studied in the course of long-term (520 days) isolation in hermetic chamber. Measured parameters included activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin time (ТT); concentrations of fibrinogen (FBG), plasminogen (PG), Willebrand factor (WF), tissue factor pathway inhibitor (TFPI), tissue plasminogen activator (TPA), and thrombomodulin (ТМ); activities of the coagulation cascade factors II, V, VII, X, VIII, IX, XI, and XII, antithrombin III (ATIII), protein С (PC), С1-inhibitor (С1), α 2 -antiplasmin (АP), TPA and TFPI. The investigation revealed a diversity of changes in plasma FBG concentration, slower blood coagulation in the intrinsic pathway and in final stage, and a relative rise in the activities of ATIII and PC-inhibited factors. The remaining parameters exhibited different trends.
ISSN:0362-1197
1608-3164
DOI:10.1134/S0362119716070082