Acid Sensitive Ion Channels as Target of Hydrogen Sulfide in Rat Trigeminal Neurons

Hydrogen sulfide (H 2 S), an endogenous gasotransmitter, was proposed to act as a signaling molecule in a wide variety of pathophysiological processes including inflammation and nociception. Acid-sensing ion channels (ASICs) are voltage-insensitive, proton-gated cation channels activated by extracel...

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Bibliographic Details
Published in:BioNanoScience 2016-12, Vol.6 (4), p.370-372
Main Authors: Mustafina, A. N., Koroleva, K. S., Giniatullin, R. A., Sitdikova, G. F.
Format: Article
Language:English
Subjects:
Acidity
Acidosis
Action potential
Biological and Medical Physics
Biomaterials
Biophysics
Circuits and Systems
Engineering
Excitability
Headache
Hydrogen sulfide
Ion channels
Ischemia
Meninges
Migraine
Nanotechnology
Nerves
Nervous system
Neurons
Pain perception
pH effects
Rodents
Sodium
Sodium channels
Stroke
Suction
Sulfides
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Summary:Hydrogen sulfide (H 2 S), an endogenous gasotransmitter, was proposed to act as a signaling molecule in a wide variety of pathophysiological processes including inflammation and nociception. Acid-sensing ion channels (ASICs) are voltage-insensitive, proton-gated cation channels activated by extracellular acidosis, and are involved in various pathologies of the nervous system including ischemia, stroke, and migraine. In this study, the effect of the H 2 S donor-sodium hydrogen sulfide (NaHS) on the firing of trigeminal (TG) nerve was explored using suction electrode recordings in peripheral branches of the TG nerve in isolated rat meninges, and patch clamp recordings of ASIC currents in isolated TG neurons. NaHS (100 μM) increased the action potential frequency of TG nerve and bath application of NaHS increased the amplitude of ASIC currents triggered by focal application of low pH solution on isolated TG neurons. We propose that activation of ASICs by H 2 S during chronic inflammation process contributes to the increased excitability of the TG system and may be implicated in the generation of nociceptive firing underlying migraine pain.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-016-0237-6