Graphene oxide nanosheets-catalyzed synthesis of novel benzylbarbiturocoumarin derivatives under green conditions

An efficient tricomponent reaction between barbituric acid (or N , N -dimethylbarbituric acid), 4-hydroxycoumarin, and a wide range of aryl aldehydes to obtain novel benzylbarbiturocoumarins is described. Starting materials were successfully condensed via three C–C bond formation by graphene oxide n...

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Bibliographic Details
Published in:Monatshefte für Chemie 2016-12, Vol.147 (12), p.2119-2126
Main Authors: Eskandari, Khalil, Karami, Bahador
Format: Article
Language:English
Subjects:
Aldehydes
Analytical Chemistry
Aromatic compounds
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Graphene
Inorganic Chemistry
Nanosheets
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Summary:An efficient tricomponent reaction between barbituric acid (or N , N -dimethylbarbituric acid), 4-hydroxycoumarin, and a wide range of aryl aldehydes to obtain novel benzylbarbiturocoumarins is described. Starting materials were successfully condensed via three C–C bond formation by graphene oxide nanosheets as an efficient, metal-free, environmentally safe, and recyclable nanocatalyst to obtain target products. The target products were obtained with high selectivities and yields (80–88 %) in H 2 O/EtOH (1:1) in the presence of graphene oxide nanosheets (0.005 g) at 80 °C. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-016-1724-8