Preoperative Treatment Planning Method for Magnetically Induced Hyperthermia Using Thermoseeds

This paper proposes a preoperative planning method for magnetically induced hyperthermia (MIH) using ferromagnetic thermoseeds based on clinical computed tomography images. Combined with external alternating magnetic field excitation, the heating model of millimeter-sized cylindrical thermoseeds and...

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Bibliographic Details
Published in:Journal of medical and biological engineering 2016-10, Vol.36 (5), p.726-732
Main Authors: Wang, Heng, Wu, Jianan, Zhang, Xianwen, Liu, Ye, Zheng, Xi, Zhuo, Zihan, Tang, Jintian
Format: Article
Language:English
Subjects:
Anatomy
Biomedical Engineering and Bioengineering
Cell Biology
Computed tomography
Conduction
Conduction heating
Conduction model
Conductive heat transfer
Cylindrical milling
Engineering
Ferromagnetism
Graphics processing units
Hyperthermia
Imaging
Necrosis
Original Article
Radiology
Real time
Temperature distribution
Temperature effects
Thermal injury
Tumors
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Summary:This paper proposes a preoperative planning method for magnetically induced hyperthermia (MIH) using ferromagnetic thermoseeds based on clinical computed tomography images. Combined with external alternating magnetic field excitation, the heating model of millimeter-sized cylindrical thermoseeds and the three-dimensional (3D) tissue bio-heat conduction model are established. The Arrhenius model is employed to evaluate the thermal injury degree of tumors and surrounding normal tissues. Based on these methods, MIH treatment planning system software is developed, where the 3D real-time model of patient anatomy is reconstructed with graphics processing unit-accelerated visualization techniques, organs and tumors are segmented, and thermoseeds are conformal-implanted to establish the temperature field distribution and the necrosis zone. This paper can provide guidance on establishment of a rational MIH preoperative planning to prediction and control of the effective therapeutic region.
ISSN:1609-0985
2199-4757
DOI:10.1007/s40846-016-0171-7