Loading…

Synthesis, characterization, and screening for analgesic and anti-inflammatory activities of new 1,3,4-oxadiazole derivatives linked to quinazolin-4-one ring

In the present study, several new 1,3,4-oxadiazole derivatives linked with quinazolin-4-one moiety were synthesized by following steps. 2-methyl -4H-3, 1-benzoxazin-4-one, and 2-phenyl -4H-3, 1-benzoxazin-4-one were synthesized in the first and second step by stirring anthranilic acid in pyridine wi...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2016-10, Vol.25 (10), p.2143-2154
Main Authors: Dewangan, Dhansay, Verma, Vinay Sagar, Nakhate, Kartik T., Tripathi, Dulal Krishna, Kashyap, Pranita, Dhongade, Hemant
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c316t-1d2ee63520251366cd0cef42d49dbd9987ba92b35c4f43b600121a1102a8b75c3
cites cdi_FETCH-LOGICAL-c316t-1d2ee63520251366cd0cef42d49dbd9987ba92b35c4f43b600121a1102a8b75c3
container_end_page 2154
container_issue 10
container_start_page 2143
container_title Medicinal chemistry research
container_volume 25
creator Dewangan, Dhansay
Verma, Vinay Sagar
Nakhate, Kartik T.
Tripathi, Dulal Krishna
Kashyap, Pranita
Dhongade, Hemant
description In the present study, several new 1,3,4-oxadiazole derivatives linked with quinazolin-4-one moiety were synthesized by following steps. 2-methyl -4H-3, 1-benzoxazin-4-one, and 2-phenyl -4H-3, 1-benzoxazin-4-one were synthesized in the first and second step by stirring anthranilic acid in pyridine with benzoyl chloride and with an acetic anhydride for 30 min at room temperature. On treatment with semicarbazide with the above synthesized intermediates, that is, 2-methyl-4H-3,1-benzoxazin-4-one, and 2-phenyl-4H-3,1-benzoxazin-4-one in the third step afforded 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide . These were introduced in cyclization reaction with different aromatic acids, aromatic aldehydes, and carbon disulfide in the next step, producing the corresponding 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-phenyl-quinazolin-4(3H)-one derivatives, 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-methyl-quinazolin-4(3H)-one derivatives, 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-phenylquinazolin-4(3H)-one derivatives and 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-methylquinazolin-4(3H)-one derivatives . Purity of these synthesized derivatives was confirmed by thin layer chromatography, melting point. Structure of the derivatives was set up by determining infrared spectroscopy, nuclear magnetic resonance, and mass spectroscopy. All the synthesized derivatives were evaluated for their analgesic and anti-inflammatory activities in mice and rats. In animal studies, the derivatives 3-[4-acetyl-5-(2-hydroxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one shown more potent analgesic activity and the derivatives 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-methylquinazolin-4(3H)-one shown more potent anti-inflammatory activity as compared to other derivatives. The results of current study indicate that cyclization of carbohydrazide group of intermediate 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide with different aromatic acids, aromatic aldehydes, and carbon disulfide produces novel quinazolin-4-one linked oxadiazole derivatives with potent analgesic and anti-inflammatory activities.
doi_str_mv 10.1007/s00044-016-1641-8
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1880850881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1880850881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-1d2ee63520251366cd0cef42d49dbd9987ba92b35c4f43b600121a1102a8b75c3</originalsourceid><addsrcrecordid>eNp1kc1OWzEQha8QlYCUB2BniW0MM_65cZYV6g8SEou2a8vX9gXDjR1sJyW8S9-1Dumim65mNPOdORqdrrtAuEKAxXUBACEoYE-xF0jVUXeKUgqqkMFx66H1TDJ-0p2V8gTAFyDkaff7-y7WR19CmRP7aLKx1efwZmpIcU5MdKTY7H0M8YGMKbeJmR4abt93JtZAQxwns1qZmvKONH3Yhhp8IWkk0f8iOOdzQdOrccG8pckT1wy2zWDbmCnEZ-9ITeRlE-J-HyJtdPQkN8uP3YfRTMWf_62z7ueXzz9uvtG7-6-3N5_uqOXYV4qOed9zyYBJ5H1vHVg_CubE0g1uuVSLwSzZwKUVo-BDD4AMDSIwo4aFtHzWXR7urnN62fhS9VPa5PZq0agUKAlKYaPwQNmcSsl-1OscVibvNILep6APKeiWgt6noFXTsIOmrPcP-fzP5f-K_gAajow1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1880850881</pqid></control><display><type>article</type><title>Synthesis, characterization, and screening for analgesic and anti-inflammatory activities of new 1,3,4-oxadiazole derivatives linked to quinazolin-4-one ring</title><source>Springer Nature</source><creator>Dewangan, Dhansay ; Verma, Vinay Sagar ; Nakhate, Kartik T. ; Tripathi, Dulal Krishna ; Kashyap, Pranita ; Dhongade, Hemant</creator><creatorcontrib>Dewangan, Dhansay ; Verma, Vinay Sagar ; Nakhate, Kartik T. ; Tripathi, Dulal Krishna ; Kashyap, Pranita ; Dhongade, Hemant</creatorcontrib><description>In the present study, several new 1,3,4-oxadiazole derivatives linked with quinazolin-4-one moiety were synthesized by following steps. 2-methyl -4H-3, 1-benzoxazin-4-one, and 2-phenyl -4H-3, 1-benzoxazin-4-one were synthesized in the first and second step by stirring anthranilic acid in pyridine with benzoyl chloride and with an acetic anhydride for 30 min at room temperature. On treatment with semicarbazide with the above synthesized intermediates, that is, 2-methyl-4H-3,1-benzoxazin-4-one, and 2-phenyl-4H-3,1-benzoxazin-4-one in the third step afforded 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide . These were introduced in cyclization reaction with different aromatic acids, aromatic aldehydes, and carbon disulfide in the next step, producing the corresponding 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-phenyl-quinazolin-4(3H)-one derivatives, 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-methyl-quinazolin-4(3H)-one derivatives, 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-phenylquinazolin-4(3H)-one derivatives and 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-methylquinazolin-4(3H)-one derivatives . Purity of these synthesized derivatives was confirmed by thin layer chromatography, melting point. Structure of the derivatives was set up by determining infrared spectroscopy, nuclear magnetic resonance, and mass spectroscopy. All the synthesized derivatives were evaluated for their analgesic and anti-inflammatory activities in mice and rats. In animal studies, the derivatives 3-[4-acetyl-5-(2-hydroxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one shown more potent analgesic activity and the derivatives 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-methylquinazolin-4(3H)-one shown more potent anti-inflammatory activity as compared to other derivatives. The results of current study indicate that cyclization of carbohydrazide group of intermediate 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide with different aromatic acids, aromatic aldehydes, and carbon disulfide produces novel quinazolin-4-one linked oxadiazole derivatives with potent analgesic and anti-inflammatory activities.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-016-1641-8</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetic anhydride ; Acids ; Aldehydes ; Analgesics ; Anthranilic acid ; Anti-inflammatory agents ; Aromatic compounds ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Carbon ; Carbon disulfide ; Cell Biology ; Inflammation ; Infrared spectroscopy ; Intermediates ; Mass spectroscopy ; Melting points ; NMR ; Nuclear magnetic resonance ; Original Research ; Oxadiazoles ; Pharmacology/Toxicology ; Pyridines ; Room temperature ; Semicarbazide ; Spectrum analysis ; Synthesis ; Thin layer chromatography</subject><ispartof>Medicinal chemistry research, 2016-10, Vol.25 (10), p.2143-2154</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Copyright Springer Science &amp; Business Media 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-1d2ee63520251366cd0cef42d49dbd9987ba92b35c4f43b600121a1102a8b75c3</citedby><cites>FETCH-LOGICAL-c316t-1d2ee63520251366cd0cef42d49dbd9987ba92b35c4f43b600121a1102a8b75c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Dewangan, Dhansay</creatorcontrib><creatorcontrib>Verma, Vinay Sagar</creatorcontrib><creatorcontrib>Nakhate, Kartik T.</creatorcontrib><creatorcontrib>Tripathi, Dulal Krishna</creatorcontrib><creatorcontrib>Kashyap, Pranita</creatorcontrib><creatorcontrib>Dhongade, Hemant</creatorcontrib><title>Synthesis, characterization, and screening for analgesic and anti-inflammatory activities of new 1,3,4-oxadiazole derivatives linked to quinazolin-4-one ring</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>In the present study, several new 1,3,4-oxadiazole derivatives linked with quinazolin-4-one moiety were synthesized by following steps. 2-methyl -4H-3, 1-benzoxazin-4-one, and 2-phenyl -4H-3, 1-benzoxazin-4-one were synthesized in the first and second step by stirring anthranilic acid in pyridine with benzoyl chloride and with an acetic anhydride for 30 min at room temperature. On treatment with semicarbazide with the above synthesized intermediates, that is, 2-methyl-4H-3,1-benzoxazin-4-one, and 2-phenyl-4H-3,1-benzoxazin-4-one in the third step afforded 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide . These were introduced in cyclization reaction with different aromatic acids, aromatic aldehydes, and carbon disulfide in the next step, producing the corresponding 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-phenyl-quinazolin-4(3H)-one derivatives, 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-methyl-quinazolin-4(3H)-one derivatives, 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-phenylquinazolin-4(3H)-one derivatives and 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-methylquinazolin-4(3H)-one derivatives . Purity of these synthesized derivatives was confirmed by thin layer chromatography, melting point. Structure of the derivatives was set up by determining infrared spectroscopy, nuclear magnetic resonance, and mass spectroscopy. All the synthesized derivatives were evaluated for their analgesic and anti-inflammatory activities in mice and rats. In animal studies, the derivatives 3-[4-acetyl-5-(2-hydroxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one shown more potent analgesic activity and the derivatives 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-methylquinazolin-4(3H)-one shown more potent anti-inflammatory activity as compared to other derivatives. The results of current study indicate that cyclization of carbohydrazide group of intermediate 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide with different aromatic acids, aromatic aldehydes, and carbon disulfide produces novel quinazolin-4-one linked oxadiazole derivatives with potent analgesic and anti-inflammatory activities.</description><subject>Acetic anhydride</subject><subject>Acids</subject><subject>Aldehydes</subject><subject>Analgesics</subject><subject>Anthranilic acid</subject><subject>Anti-inflammatory agents</subject><subject>Aromatic compounds</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carbon</subject><subject>Carbon disulfide</subject><subject>Cell Biology</subject><subject>Inflammation</subject><subject>Infrared spectroscopy</subject><subject>Intermediates</subject><subject>Mass spectroscopy</subject><subject>Melting points</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Research</subject><subject>Oxadiazoles</subject><subject>Pharmacology/Toxicology</subject><subject>Pyridines</subject><subject>Room temperature</subject><subject>Semicarbazide</subject><subject>Spectrum analysis</subject><subject>Synthesis</subject><subject>Thin layer chromatography</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kc1OWzEQha8QlYCUB2BniW0MM_65cZYV6g8SEou2a8vX9gXDjR1sJyW8S9-1Dumim65mNPOdORqdrrtAuEKAxXUBACEoYE-xF0jVUXeKUgqqkMFx66H1TDJ-0p2V8gTAFyDkaff7-y7WR19CmRP7aLKx1efwZmpIcU5MdKTY7H0M8YGMKbeJmR4abt93JtZAQxwns1qZmvKONH3Yhhp8IWkk0f8iOOdzQdOrccG8pckT1wy2zWDbmCnEZ-9ITeRlE-J-HyJtdPQkN8uP3YfRTMWf_62z7ueXzz9uvtG7-6-3N5_uqOXYV4qOed9zyYBJ5H1vHVg_CubE0g1uuVSLwSzZwKUVo-BDD4AMDSIwo4aFtHzWXR7urnN62fhS9VPa5PZq0agUKAlKYaPwQNmcSsl-1OscVibvNILep6APKeiWgt6noFXTsIOmrPcP-fzP5f-K_gAajow1</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Dewangan, Dhansay</creator><creator>Verma, Vinay Sagar</creator><creator>Nakhate, Kartik T.</creator><creator>Tripathi, Dulal Krishna</creator><creator>Kashyap, Pranita</creator><creator>Dhongade, Hemant</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20161001</creationdate><title>Synthesis, characterization, and screening for analgesic and anti-inflammatory activities of new 1,3,4-oxadiazole derivatives linked to quinazolin-4-one ring</title><author>Dewangan, Dhansay ; Verma, Vinay Sagar ; Nakhate, Kartik T. ; Tripathi, Dulal Krishna ; Kashyap, Pranita ; Dhongade, Hemant</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-1d2ee63520251366cd0cef42d49dbd9987ba92b35c4f43b600121a1102a8b75c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetic anhydride</topic><topic>Acids</topic><topic>Aldehydes</topic><topic>Analgesics</topic><topic>Anthranilic acid</topic><topic>Anti-inflammatory agents</topic><topic>Aromatic compounds</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carbon</topic><topic>Carbon disulfide</topic><topic>Cell Biology</topic><topic>Inflammation</topic><topic>Infrared spectroscopy</topic><topic>Intermediates</topic><topic>Mass spectroscopy</topic><topic>Melting points</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Original Research</topic><topic>Oxadiazoles</topic><topic>Pharmacology/Toxicology</topic><topic>Pyridines</topic><topic>Room temperature</topic><topic>Semicarbazide</topic><topic>Spectrum analysis</topic><topic>Synthesis</topic><topic>Thin layer chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dewangan, Dhansay</creatorcontrib><creatorcontrib>Verma, Vinay Sagar</creatorcontrib><creatorcontrib>Nakhate, Kartik T.</creatorcontrib><creatorcontrib>Tripathi, Dulal Krishna</creatorcontrib><creatorcontrib>Kashyap, Pranita</creatorcontrib><creatorcontrib>Dhongade, Hemant</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dewangan, Dhansay</au><au>Verma, Vinay Sagar</au><au>Nakhate, Kartik T.</au><au>Tripathi, Dulal Krishna</au><au>Kashyap, Pranita</au><au>Dhongade, Hemant</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization, and screening for analgesic and anti-inflammatory activities of new 1,3,4-oxadiazole derivatives linked to quinazolin-4-one ring</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2016-10-01</date><risdate>2016</risdate><volume>25</volume><issue>10</issue><spage>2143</spage><epage>2154</epage><pages>2143-2154</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>In the present study, several new 1,3,4-oxadiazole derivatives linked with quinazolin-4-one moiety were synthesized by following steps. 2-methyl -4H-3, 1-benzoxazin-4-one, and 2-phenyl -4H-3, 1-benzoxazin-4-one were synthesized in the first and second step by stirring anthranilic acid in pyridine with benzoyl chloride and with an acetic anhydride for 30 min at room temperature. On treatment with semicarbazide with the above synthesized intermediates, that is, 2-methyl-4H-3,1-benzoxazin-4-one, and 2-phenyl-4H-3,1-benzoxazin-4-one in the third step afforded 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide . These were introduced in cyclization reaction with different aromatic acids, aromatic aldehydes, and carbon disulfide in the next step, producing the corresponding 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-phenyl-quinazolin-4(3H)-one derivatives, 3-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2-methyl-quinazolin-4(3H)-one derivatives, 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-phenylquinazolin-4(3H)-one derivatives and 3-(5-aryl-1,3,4-oxadiazol-2-yl)-2-methylquinazolin-4(3H)-one derivatives . Purity of these synthesized derivatives was confirmed by thin layer chromatography, melting point. Structure of the derivatives was set up by determining infrared spectroscopy, nuclear magnetic resonance, and mass spectroscopy. All the synthesized derivatives were evaluated for their analgesic and anti-inflammatory activities in mice and rats. In animal studies, the derivatives 3-[4-acetyl-5-(2-hydroxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one shown more potent analgesic activity and the derivatives 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-phenylquinazolin-4(3H)-one and 3-[4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2-methylquinazolin-4(3H)-one shown more potent anti-inflammatory activity as compared to other derivatives. The results of current study indicate that cyclization of carbohydrazide group of intermediate 2-methyl-4-oxoquinazoline-3(4H)-carbohydrazide and 2-phenyl-4-oxoquinazoline-3(4H)-carbohydrazide with different aromatic acids, aromatic aldehydes, and carbon disulfide produces novel quinazolin-4-one linked oxadiazole derivatives with potent analgesic and anti-inflammatory activities.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-016-1641-8</doi><tpages>12</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1054-2523
ispartof Medicinal chemistry research, 2016-10, Vol.25 (10), p.2143-2154
issn 1054-2523
1554-8120
language eng
recordid cdi_proquest_journals_1880850881
source Springer Nature
subjects Acetic anhydride
Acids
Aldehydes
Analgesics
Anthranilic acid
Anti-inflammatory agents
Aromatic compounds
Biochemistry
Biomedical and Life Sciences
Biomedicine
Carbon
Carbon disulfide
Cell Biology
Inflammation
Infrared spectroscopy
Intermediates
Mass spectroscopy
Melting points
NMR
Nuclear magnetic resonance
Original Research
Oxadiazoles
Pharmacology/Toxicology
Pyridines
Room temperature
Semicarbazide
Spectrum analysis
Synthesis
Thin layer chromatography
title Synthesis, characterization, and screening for analgesic and anti-inflammatory activities of new 1,3,4-oxadiazole derivatives linked to quinazolin-4-one ring
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T10%3A40%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis,%20characterization,%20and%20screening%20for%20analgesic%20and%20anti-inflammatory%20activities%20of%20new%201,3,4-oxadiazole%20derivatives%20linked%20to%20quinazolin-4-one%20ring&rft.jtitle=Medicinal%20chemistry%20research&rft.au=Dewangan,%20Dhansay&rft.date=2016-10-01&rft.volume=25&rft.issue=10&rft.spage=2143&rft.epage=2154&rft.pages=2143-2154&rft.issn=1054-2523&rft.eissn=1554-8120&rft_id=info:doi/10.1007/s00044-016-1641-8&rft_dat=%3Cproquest_cross%3E1880850881%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c316t-1d2ee63520251366cd0cef42d49dbd9987ba92b35c4f43b600121a1102a8b75c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1880850881&rft_id=info:pmid/&rfr_iscdi=true