The effect of quercetin on hepatic differentiation of human adipose-derived mesenchymal stem cells

Human adipose-derived mesenchymal stem cells (MSCs) can be stimulated to differentiate into hepatic cells. MSC differentiation was induced by fibroblast growth factor-4, hepatocyte growth factor, oncostatin M, and dexamethasone. The influence of quercetin on MSC hepatic differentiation in culture wa...

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Bibliographic Details
Published in:Cell and tissue biology 2016-09, Vol.10 (5), p.357-364
Main Authors: Pinchuk, S. V., Vasilevich, I. B., Kvacheva, Z. B., Volotovski, I. D.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Cell differentiation
Immunology
Life Sciences
Mesenchymal stem cells
Mesenchyme
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Summary:Human adipose-derived mesenchymal stem cells (MSCs) can be stimulated to differentiate into hepatic cells. MSC differentiation was induced by fibroblast growth factor-4, hepatocyte growth factor, oncostatin M, and dexamethasone. The influence of quercetin on MSC hepatic differentiation in culture was assayed, and 1 or 10 μmole/L quercetin added into the induction medium enhanced the manifestation of MSC hepatic differentiation. Urea secretion, cytokeratin 19 expression, and α-fetoprotein synthesis were increased. Quercetin modulated CYP1A–cytochrome P450 activity in the differentiated cells. MSCs differentiated in the presence of quercetin exhibited higher viability and resistance to oxidative stress.
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X16050102