Synthesis of Chiral Phosphazene Bases

Air-stable and crystalline tetraaminophosphonium tetrafluoroborates possessing chiral, enantiomerically pure 1,2-diamine moiety have been synthesized by a three-step sequential one-pot approach. The tetrafluoroborate salts can be purified by recrystallization or chromatography and subsequently conve...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2016-08, Vol.52 (8), p.541-545
Main Authors: Priede, Martins, Priede, Elina, Saame, Jaan, Leito, Ivo, Suna, Edgars
Format: Article
Language:English
Subjects:
Basicity
Chemistry
Chemistry and Materials Science
Chromatography
Diamines
Enantiomers
Organic Chemistry
Pharmacy
Phosphazene
Recrystallization
Spectrophotometry
Tetrahydrofuran
Titration
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Summary:Air-stable and crystalline tetraaminophosphonium tetrafluoroborates possessing chiral, enantiomerically pure 1,2-diamine moiety have been synthesized by a three-step sequential one-pot approach. The tetrafluoroborate salts can be purified by recrystallization or chromatography and subsequently converted to the phosphazene bases by treatment with t- BuOK. Basicity values in tetrahydrofuran have been measured for the obtained phosphazene bases by means of spectrophotometric titration.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-016-1927-2