Ameliorative effects of Bauhinia acuminata L stem bark powder against chronic arsenicosis in rats

Arsenic poisoning is one of the major causes of chronic human illness and mortality in Bengal Delta plain with limited treatment option. The present study was conducted to evaluate the ameliorating effect of Bauhinia acuminata L (Leguminosae: Caesalpinioideae) stem-bark powder against sodium arsenit...

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Published in:Toxicology and environmental health sciences 2016-09, Vol.8 (3), p.258-262
Main Authors: De, Amartya, Nath, Sarmila, Bandyopadhyay, Susanta Kumar, Mandal, Tapan Kumar, Das, Anup Kumar
Format: Article
Language:English
Subjects:
Arsenates
Arsenic
Arsenite
Bark
Bauhinia
Bioaccumulation
Biomedical and Life Sciences
Biomedicine
Chronic toxicity
Drinking water
Environmental Health
Feces
Hair
Pharmacology/Toxicology
Poisoning
Powder
Public health
Rats
Research Article
Sodium
Sodium arsenite
Toxicity
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Summary:Arsenic poisoning is one of the major causes of chronic human illness and mortality in Bengal Delta plain with limited treatment option. The present study was conducted to evaluate the ameliorating effect of Bauhinia acuminata L (Leguminosae: Caesalpinioideae) stem-bark powder against sodium arsenite (NaAsO 2 ) induced toxicity. Forty eight adult albino rats were divided into four groups viz., D 0 , D 1 , D 2 and D 3 . Sodium arsenite was administered @4 mg/kg daily in drinking water in groups D 1 , D 2 and D 3 for 90 days; control group (D0) received water for 120 days. The D 1 group of animals received water, instead of arsenic during 91-120 days, while rats of group D 2 and D 3 were orally treated with stem bark powder @350 mg/kg (1/10 th dose of LD 50 ) and 175 mg/kg (1/20 th dose of LD 50 ) respectively daily during the period. Analysis of arsenic concentrations in tissue samples, hair and faeces showed that treatment with B. acuminata stem bark powder significantly (p
ISSN:2005-9752
2233-7784
DOI:10.1007/s13530-016-0283-z