N-substituted 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetamides

In reaction of 6-aminouracyles with ethyl oxochloroacetate ethyl 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetates were obtained, which by further reaction with various amines afforded oxo(pyrimidinyl)acetamides. According to the data of biological tests, the synthesized compounds...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2016, Vol.52 (8), p.1179-1182
Main Authors: Gasparyan, S. P., Alexanyan, M. V., Arutyunyan, G. K., Martirosyan, A. H., Paronikyan, R. V., Stepanyan, H. M.
Format: Article
Language:English
Subjects:
Amines
Antibacterial materials
Anticancer properties
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:In reaction of 6-aminouracyles with ethyl oxochloroacetate ethyl 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetates were obtained, which by further reaction with various amines afforded oxo(pyrimidinyl)acetamides. According to the data of biological tests, the synthesized compounds showed low antibacterial and antitumor activity.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428016080145