A new method for loading mesoporous silica nanoparticles with drugs: Sol–gel synthesis using drug micelles as a template

It has been shown that mesoporous nanocontainers from SiO 2 may be obtained by the sol–gel synthesis using drug (Miramistin) micelles as a template. The nanocontainers resulting from the combination of the stages of their synthesis and loading are characterized by a very high content of the drug (no...

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Bibliographic Details
Published in:Colloid journal of the Russian Academy of Sciences 2016-09, Vol.78 (5), p.586-595
Main Authors: Dement’eva, O. V., Senchikhin, I. N., Kartseva, M. E., Ogarev, V. A., Zaitseva, A. V., Matushkina, N. N., Rudoy, V. M.
Format: Article
Language:English
Subjects:
Aqueous solutions
Chemistry
Chemistry and Materials Science
Desorption
Micelles
Polymer Sciences
Silicon dioxide
Sol-gel processes
Surfaces and Interfaces
Synthesis
Thin Films
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Summary:It has been shown that mesoporous nanocontainers from SiO 2 may be obtained by the sol–gel synthesis using drug (Miramistin) micelles as a template. The nanocontainers resulting from the combination of the stages of their synthesis and loading are characterized by a very high content of the drug (no less than 0.9 g per 1 g of SiO 2 ). The kinetics of Miramistin desorption from the mesoporous particles into an aqueous medium has been studied under static and quasi-dynamic conditions. The desorption has been shown to rather strongly depend on pH. Possible mechanisms of the desorption process have been discussed.
ISSN:1061-933X
1608-3067
DOI:10.1134/S1061933X16050045