Electrochemical determination of riboflavin using a synthesized ethyl[(methythio)carbonothioyl] glycinate monolayer modified gold electrode

• Published in: Journal of analytical chemistry (New York, N.Y.) N.Y.), 2016-10, Vol.71 (10), p.1057-1062
• Main Authors: Karimian, F., Rounaghi, G. H., Mohadeszadeh, M.
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Buffer solutions; Chemical properties; Chemical sensors; Chemistry; Chemistry and Materials Science; Electric properties; Electrochemical analysis; Electrochemical impedance spectroscopy; Electrodes; Gold; Methyl compounds; Monolayers; Riboflavin; Self-assembled monolayers; Self-assembly; Synthesis; Vitamins; Voltammetry
• ISSN: 1061-9348; 1608-3199
• DOI: 10.1134/S1061934816080062

The surface of a gold disk electrode, for the first time, was modified with a self-assembled monolayer of a synthesized compound, ethyl [(methythio)carbonothioyl] glycinate (ECTG), for construction of an electrode sensitive to riboflavin (vitamin B 2 ). The electrochemical properties of the monolayer assembled on the gold disk were investigated by cyclic voltammetry and electrochemical impedance spectroscopy. Under the optimized conditions, the voltammetric peak currents resulting from vitamin B 2 (VB 2 ) species were linear for VB 2 concentrations in the range from 10 –6 to 10 –2 M. The effect of pH, type of buffer solution and scan rate on the response of the modified electrode was studied. The constructed electrochemical sensor responses very well to VB 2 in the presence of most common vitamins. Finally, the performance of the Au–ECTG modified electrode was successfully tested for electrochemical detection of VB 2 in a pharmaceutical sample.