Study on the inclusion behaviour and solid inclusion complex of lomustine with cyclodextrins

The water soluble solid inclusion complex of three native or modified cyclodextrins (CDs) including β -cyclodextrin ( β -CD), hydroxypropyl- β -cyclodextrin (Hp- β -CD) and 2,6-di- o -methyl- β -cyclodextrin (DIME- β -CD) and Lomustine (CCNU) were presented with the orthogonal experiment investigati...

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Bibliographic Details
Published in:Journal of inclusion phenomena and macrocyclic chemistry 2016-10, Vol.86 (1-2), p.45-54
Main Authors: Sun, Wei, She, Meng-Yao, Yang, Zheng, Zhu, Yue-Lu, Ma, Si-Yue, Shi, Zhen, Li, Jian-Li
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Crystallography and Scattering Methods
Cyclodextrins
Food Science
Inclusion complexes
Infrared analysis
Intermolecular forces
Microphotographs
NMR
Nuclear magnetic resonance
Organic Chemistry
Original Article
Thermal stability
Thermogravimetric analysis
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Summary:The water soluble solid inclusion complex of three native or modified cyclodextrins (CDs) including β -cyclodextrin ( β -CD), hydroxypropyl- β -cyclodextrin (Hp- β -CD) and 2,6-di- o -methyl- β -cyclodextrin (DIME- β -CD) and Lomustine (CCNU) were presented with the orthogonal experiment investigation of the reaction conditions. The inclusion behaviors were comparatively investigated by nuclear magnetic resonance in combination with infrared spectroscopy, thermogravimetric analysis, X-ray diffractometry and scanning electron microphotographs. The experimental results jointly demonstrated that the entrance of CCNU into the cavity of the CDs by intermolecular forces as well as hydrophobic forces and resulting in the significantly improvement of the thermostability of CCNU. Graphical Abstract
ISSN:1388-3127
1573-1111
DOI:10.1007/s10847-016-0640-1