Three-component synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylates

A procedure has been developed for the synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylate by three-component reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with hydrogen halides in methanol.

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Bibliographic Details
Published in:Russian journal of organic chemistry 2016-07, Vol.52 (7), p.970-973
Main Authors: Ershov, O. V., Lipin, K. V., Nasakin, O. E.
Format: Article
Language:English
Subjects:
Carboxylates
Chemistry
Chemistry and Materials Science
Halides
Organic Chemistry
Synthesis
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Summary:A procedure has been developed for the synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylate by three-component reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with hydrogen halides in methanol.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428016070071