Synthesis of 3-oxoesters and functional derivatives of pyrimidin-4(3Н)-one based on 1-(2,6-dihalophenyl)cyclopropan-1-carboxylic acids

Special features of the synthesis and chemical transformations of novel functional derivatives of 6-[1-(2,6-dihalophenyl)cyclopropyl]pyrimidin-4(3 H )-one and ethyl esters of 3-[1-(2,6-dihalophenyl)cyclopropyl]-2-methyl-3-oxopropanoic acids prepared from 2-(2,6-dihalophenyl)acetonitriles have been r...

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Bibliographic Details
Published in:Russian journal of general chemistry 2017-02, Vol.87 (2), p.224-230
Main Authors: Novakov, I. A., Yablokov, A. S., Navrotskii, M. B., Mkrtchyan, A. S., Vernigora, A. A., Babushkin, A. S., Kachala, V. V., Ruchko, E. A.
Format: Article
Language:English
Subjects:
Carboxylic acids
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Ethyl esters
Organic compounds
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Summary:Special features of the synthesis and chemical transformations of novel functional derivatives of 6-[1-(2,6-dihalophenyl)cyclopropyl]pyrimidin-4(3 H )-one and ethyl esters of 3-[1-(2,6-dihalophenyl)cyclopropyl]-2-methyl-3-oxopropanoic acids prepared from 2-(2,6-dihalophenyl)acetonitriles have been revealed. Novel achiral structural analogs of experimental anti-HIV agent МС-1501 have been synthesized.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217020128