Synthesis of some novel 1,2,3-triazole derivatives containing kojic acid moiety and evaluation for their antioxidant activity

A series of novel 1,2,3-triazole derivatives containing kojic acid moiety were synthesized by 1,3-dipolar cycloaddition reaction of 2-(azidomethyl)-5-hydroxy-4 H -pyran-4-one and 2-(azidomethyl)-5-benzyloxy-4 H -pyran-4-one with different alkynes in 41–99% yields. In the case of terminal alkynes, th...

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Bibliographic Details
Published in:Monatshefte für Chemie 2017-05, Vol.148 (5), p.917-923
Main Authors: Saraei, Mahnaz, Ghasemi, Zarrin, Dehghan, Gholamreza, Hormati, Marhamat, Ojaghi, Khadijeh
Format: Article
Language:English
Subjects:
Alkynes
Analytical Chemistry
Antioxidants
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cycloaddition
Hydroxyl groups
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
Triazoles
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Summary:A series of novel 1,2,3-triazole derivatives containing kojic acid moiety were synthesized by 1,3-dipolar cycloaddition reaction of 2-(azidomethyl)-5-hydroxy-4 H -pyran-4-one and 2-(azidomethyl)-5-benzyloxy-4 H -pyran-4-one with different alkynes in 41–99% yields. In the case of terminal alkynes, the reactions occurred in the presence of Cu(I) catalyst. The antioxidant activity of the synthesized compounds containing 5-hydroxyl group was evaluated by 1,1-diphenyl-2-picrylhydrazyl method. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-016-1844-1