Obtaining nonspherical poly(alkylcyanoacrylate) nanoparticles by the stretching method applied with a marketed water-soluble film

This work was aimed to produce elongated nanoparticles of clinical interest by the stretching method. Polymer films prepared from material recovered from the dissolution of a marketed stretchable water-soluble film were loaded with 10% of poly(isobutylcyanoacrylate) nanoparticles. The films were elo...

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Bibliographic Details
Published in:International journal of polymeric materials 2017-05, Vol.66 (8), p.416-424
Main Authors: Palazzo, Claudio, Ponchel, Gilles, Vachon, Jean Jacques, Villebrun, Sarah, Agnely, Florence, Vauthier, Christine
Format: Article
Language:English
Subjects:
Chemical Sciences
Galenic pharmacology
Life Sciences
Nanoparticles
Pharmaceutical sciences
poly(isobutylcyanoacrylate)
polymer film
Polymers
shape factor
stretching
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Summary:This work was aimed to produce elongated nanoparticles of clinical interest by the stretching method. Polymer films prepared from material recovered from the dissolution of a marketed stretchable water-soluble film were loaded with 10% of poly(isobutylcyanoacrylate) nanoparticles. The films were elongated at 50°C to 230% of their initial lengths. The shape factor of the nanoparticles recovered after elongation was consistent with stretching conditions applied on the film. This work has demonstrated the feasibility of the preparation of nonspherical poly(isobutylcyanoacrylate) nanoparticles by the stretching method and described conditions to apply the method.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2016.1233420