sup 68^Ga-PSMA-11 PET/CT in primary staging of prostate cancer: PSA and Gleason score predict the intensity of tracer accumulation in the primary tumour

Purpose Prostate cancer (PC) cells typically show increased expression of prostate-specific membrane antigen (PSMA), which can be visualized by 68Ga-PSMA-11 PET/CT. The aim of this study was to assess the intensity of 68Ga-PSMA-11 uptake in the primary tumor and metastases in patients with biopsy-pr...

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Published in:European journal of nuclear medicine and molecular imaging 2017-06, Vol.44 (6), p.941
Main Authors: Uprimny, Christian, Kroiss, Alexander Stephan, Decristoforo, Clemens, Fritz, Josef, von Guggenberg, Elisabeth, Kendler, Dorota, Scarpa, Lorenza, Di Santo, Gianpaolo, Roig, Llanos Geraldo, Maffey-steffan, Johanna, Horninger, Wolfgang, Virgolini, Irene Johanna
Format: Article
Language:English
Subjects:
Antigens
Metastasis
Prostate cancer
Tomography
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Summary:Purpose Prostate cancer (PC) cells typically show increased expression of prostate-specific membrane antigen (PSMA), which can be visualized by 68Ga-PSMA-11 PET/CT. The aim of this study was to assess the intensity of 68Ga-PSMA-11 uptake in the primary tumor and metastases in patients with biopsy-proven PC prior to therapy, and to determine whether a correlation exists between the primary tumour-related 68Ga-PSMA-11 accumulation and the Gleason score (GS) or prostate-specific antigen (PSA) level. Methods Ninety patients with transrectal ultrasound biopsy-proven PC (GS 6-10; median PSA: 9.7 ng/ml) referred for 68Ga-PSMA-11 PET/CT were retrospectively analyzed. PET images were analyzed visually and semiquantitatively by measuring the maximum standardized uptake value (SUVmax). The SUVmax of the primary tumor and pathologic lesions suspicious for lymphatic or distant metastases were then compared to the physiologic background activity of normal prostate tissue and gluteal muscle. The SUVmax of the primary tumor was assessed in relation to both PSA level and GS. Results Eighty-two patients (91.1%) demonstrated pathologic tracer accumulation in the primary tumor that exceeded physiologic tracer uptake in normal prostate tissue (median SUVmax: 12.5 vs. 3.9). Tumors with GS of 6, 7a (3+4) and 7b (4+3) showed significantly lower 68Ga-PSMA-11 uptake, with median SUVmax of 5.9, 8.3 and 8.2, respectively, compared to patients with GS >7 (median SUVmax: 21.2; p
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-017-3631-6