Naphthacemycins, novel circumventors of [beta]-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities

Screening for circumventors of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) led us to find 17 novel antibiotics, naphthacemycins A1 -A11 , B1 -B4 and C1 -C2 . The naphthacemycins were isolated from a cultured broth of Streptomyces sp. KB-3346-5 by repeated silica gel col...

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Bibliographic Details
Published in:Journal of antibiotics 2017-05, Vol.70 (5), p.562
Main Authors: Fukumoto, Atsushi, Kim, Yong-pil, Matsumoto, Atsuko, Takahashi, Yoko, Suzuki, Makoto, Onodera, Hideyuki, Tomoda, Hiroshi, Matsui, Hidehito, Hanaki, Hideaki, Iwatsuki, Masato, Omura, Satoshi, Shiomi, Kazuro
Format: Article
Language:English
Subjects:
Antibiotics
Fermentation
Liquid chromatography
Silica
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Summary:Screening for circumventors of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) led us to find 17 novel antibiotics, naphthacemycins A1 -A11 , B1 -B4 and C1 -C2 . The naphthacemycins were isolated from a cultured broth of Streptomyces sp. KB-3346-5 by repeated silica gel column chromatography and HPLC. Naphthacemycins enhanced imipenem activity 100-500 times against MRSA at 0.5 μg ml-1 , and naphthacemycins A4 -A11 themselves showed MIC50 values of 1-4 μg ml-1 against 22 MRSA strains.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2017.28