An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid

3,5-Dimethoxy-2,4-difluorobenzoic acid, as a key intermediate for preparing an impurity of moxifloxacin, was synthesised from 2,3,4,5-tetrafluorobenzoic acid in moderate yield by nitration, methoxyl substitution, reduction of NO2, diazotisation and reduction. The structures of the intermediates and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of chemical research 2017-04, Vol.41 (4), p.239-240
Main Authors: Zhang, Mingguang, Qiu, Lin, Yu, Shuitao, Chen, Zaixin, Wang, Shifa
Format: Article
Language:English
Subjects:
Acids
Chemical reduction
Chemical synthesis
Impurities
Nitration
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:3,5-Dimethoxy-2,4-difluorobenzoic acid, as a key intermediate for preparing an impurity of moxifloxacin, was synthesised from 2,3,4,5-tetrafluorobenzoic acid in moderate yield by nitration, methoxyl substitution, reduction of NO2, diazotisation and reduction. The structures of the intermediates and the target compound were identified and determined with IR, NMR and HRMS (ESI).
ISSN:1747-5198
2047-6507
DOI:10.3184/174751917X14902201357383