Genome-wide DNA methylation and expression analyses in the nucleus accumbens identifies coordinated regulation of receptor trafficking regulators

DNA methylation modifications have been associated with alcohol use and proposed to contribute to alcohol abuse disorders, however the downstream molecular and cellular consequences remain obscure. Together these data support a model of DNA methylation serving a coordinating role in regulating the l...

Full description

Saved in:
Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2017-05, Vol.60, p.206-206
Main Authors: Cervera-Juanes, R, Wilhem, L.J, Grant, K.A, Ferguson, B
Format: Article
Language:English
Subjects:
Abuse
Activation analysis
Alcohol use
Alcohols
Bisulfite
CpG islands
Deoxyribonucleic acid
DNA
DNA methylation
Drinking behavior
Drug abuse
Gene expression
Genomes
Glutamic acid receptors (ionotropic)
Light levels
N-Methyl-D-aspartic acid receptors
Nucleus accumbens
Protein transport
Psychiatry
Synaptic plasticity
γ-Aminobutyric acid A receptors
γ-Aminobutyric acid B receptors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:DNA methylation modifications have been associated with alcohol use and proposed to contribute to alcohol abuse disorders, however the downstream molecular and cellular consequences remain obscure. Together these data support a model of DNA methylation serving a coordinating role in regulating the levels of GABAA, GABAB and NMDA receptors in...
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2017.02.197