Widespread sucralose exposure in a randomized clinical trial in healthy young adults

ABSTRACT Background: Low-calorie sweeteners (LCSs) are found in many foods and beverages, but consumers may not realize their presence, and their role in appetite, weight, and health is controversial. Although consumption limits based on toxicologic safety are well established, the threshold require...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2017-04, Vol.105 (4), p.820-823
Main Authors: Sylvetsky, Allison C, Walter, Peter J, Garraffo, H Martin, Robien, Kim, Rother, Kristina I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Appetite
Beverages
Carbonated Beverages
Carbonation
Clinical trials
Consumers
Consumption
Diaries
Diet
Energy Intake
Environmental Exposure - analysis
Exposure
Female
Food
Gastrointestinal Microbiome - drug effects
Humans
Intestinal microflora
Male
Non-Nutritive Sweeteners
Nutrition
Nutrition Surveys
Reference Values
Sucralose
Sucrose - analogs & derivatives
Sucrose - pharmacology
Sucrose - urine
Sweeteners
Threshold limits
Urine
Weight
Young Adult
Young adults
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Summary:ABSTRACT Background: Low-calorie sweeteners (LCSs) are found in many foods and beverages, but consumers may not realize their presence, and their role in appetite, weight, and health is controversial. Although consumption limits based on toxicologic safety are well established, the threshold required to exert clinically relevant metabolic effects is unknown. Objectives: This study aimed to determine whether individuals who do not report consumption of LCSs can be correctly characterized as “unexposed” and to investigate whether instructions to avoid LCSs are effective in minimizing exposure. Design: Eighteen healthy 18- to 35-y-old “nonconsumers” (
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.116.144402