Interaction of EGFR to [delta]-catenin leads to [delta]-catenin phosphorylation and enhances EGFR signaling

Expression of δ-catenin reportedly increases during late stage prostate cancer. Furthermore, it has been demonstrated that expression of EGFR is enhanced in hormone refractory prostate cancer. In this study, we investigated the possible correlation between EGFR and δ-catenin in prostate cancer cells...

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Bibliographic Details
Published in:Scientific reports 2016-02, Vol.6, p.21207
Main Authors: He, Yongfeng, Ryu, Taeyong, Shrestha, Nensi, Yuan, Tingting, Kim, Hangun, Shrestha, Hridaya, Cho, Young-chang, Seo, Young-woo, Song, Woo Keun, Kim, Kwonseop
Format: Article
Language:English
Subjects:
Catenin
E-cadherin
Epidermal growth factor receptors
Kinases
Phosphorylation
Prostate cancer
Signal transduction
Src protein
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Summary:Expression of δ-catenin reportedly increases during late stage prostate cancer. Furthermore, it has been demonstrated that expression of EGFR is enhanced in hormone refractory prostate cancer. In this study, we investigated the possible correlation between EGFR and δ-catenin in prostate cancer cells. We found that EGFR interacted with δ-catenin and the interaction decreased in the presence of EGF. We also demonstrated that, on one hand, EGFR phosphorylated δ-catenin in a Src independent manner in the presence of EGF and on the other hand, δ-catenin enhanced protein stability of EGFR and strengthened the EGFR/Erk1/2 signaling pathway. Our findings added a new perspective to the interaction of EGFR to the E-cadherin complex. They also provided novel insights to the roles of δ-catenin in prostate cancer cells.
ISSN:2045-2322
DOI:10.1038/srep21207