The effect of space flight on the protein composition of the exhaled breath condensate of cosmonauts

As a part of development of medicine for extreme situations, we determined, for the first time, the protein composition of the exhaled breath condensate (EBC) of cosmonauts before and after long-lasting orbital flights on the International Space Station (ISS). The analysis was performed by electrosp...

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Bibliographic Details
Published in:Russian chemical bulletin 2016-11, Vol.65 (11), p.2745-2750
Main Authors: Fedorchenko, K. Yu, Ryabokon’, A. M., Kononikhin, A. S., Mitrofanov, S. I., Mikhant’eva, E. A., Spasskii, A. I., Sukhodolov, I. R., Popov, I. A., Polyakov, A. V., Larina, I. M., Nikolaev, E. N., Varfolomeev, S. D.
Format: Article
Language:English
Subjects:
Breath tests
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Composition effects
Condensates
Cosmonauts
Cyclotron resonance
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Immune system
Inorganic Chemistry
International Space Station
Ionization
Ions
Landing
Mass spectrometry
Organic Chemistry
Proteins
Space flight
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Summary:As a part of development of medicine for extreme situations, we determined, for the first time, the protein composition of the exhaled breath condensate (EBC) of cosmonauts before and after long-lasting orbital flights on the International Space Station (ISS). The analysis was performed by electrospray ionization ion cyclotron resonance mass spectrometry. The pattern of variation of the protein composition of the exhaled air during preflight preparation, at the time of landing, and seven days after landing was elucidated. Forty-four proteins, which appeared in the exhaled breath condensate of the cosmonauts after a long orbital flight and landing and were absent before the flight, were detected. These proteins included the immune response proteins, indicating cell and blood vessel damage. In some cases, a temporary appearance of cancer markers was noted.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-016-1645-z