Downregulated myostatin signaling does not enhance protein kinase B/Akt phosphorylation in skeletal muscle of low birthweight neonatal pigs

An abstract of a study by Chen et al determining the impact low protein synthesis to low birthweight (LBWT) neonatal pigs is presented. Their data suggest that although abundance of myostatin (MSTN) was lower and MSTN signaling was downregulated, these changes do not explain the diminished protein s...

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Bibliographic Details
Published in:Journal of animal science 2017-03, Vol.95, p.64
Main Authors: Chen, Y, McCauley, S R, Rhoads, R P, El-Kadi, S W
Format: Article
Language:English
Subjects:
Abundance
AKT protein
Birth weight
Hogs
Kinases
Myostatin
Neonates
Phosphorylation
Physical growth
Protein biosynthesis
Protein synthesis
Skeletal muscle
Weight
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Summary:An abstract of a study by Chen et al determining the impact low protein synthesis to low birthweight (LBWT) neonatal pigs is presented. Their data suggest that although abundance of myostatin (MSTN) was lower and MSTN signaling was downregulated, these changes do not explain the diminished protein synthesis rates previously observed in skeletal muscle of LBWT pigs. Thus it is likely that downregulated MSTN signaling may be a compensatory mechanism rather than the cause for the impaired muscle growth in LBWT neonatal pigs.
ISSN:0021-8812
1525-3163
DOI:10.2527/asasmw.2017.12.136