EFFECT OF AXIAL LENGTH ON PERIPAPILLARY RETINAL NERVE FIBRE LAYER THICKNESS MEASURED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

ABSTRACT Objective: To determine the relationship between mean axial length and mean peripapillary retinal nerve fibre layer (RNFL) thickness using spectral domain optical coherence tomography (SD OCT) in healthy subjects. INTRODUCTION Measurement of retinal nerve fibre layer (RNFL) thickness is pot...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2017-04 (2), p.238
Main Authors: Mehboob, Mohammad Asim, Ul Islam, Qamar, Yaqub, Muhammad Amer
Format: Article
Language:English
Subjects:
Age
Gender
Glaucoma
Ophthalmology
Optics
Statistical analysis
Tomography
Variance analysis
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Summary:ABSTRACT Objective: To determine the relationship between mean axial length and mean peripapillary retinal nerve fibre layer (RNFL) thickness using spectral domain optical coherence tomography (SD OCT) in healthy subjects. INTRODUCTION Measurement of retinal nerve fibre layer (RNFL) thickness is potentially useful and sensitive indicator for early detection of glaucoma as thinning of the peripapillary RNFL may be an early sign of structural damage in patients with glaucoma1,2. [...]RNFL thinning often occurs prior to clinically detectable vision loss, optic disc changes and appearance of visual field loss2,3. Optical coherence tomography (OCT) is a non-invasive diagnostic modality that allows cross-sectional imaging of the retina and optic nerve head, enabling measurement of thickness of RNFL. The new generation of spectral domain (SD) OCT with high speed image acquisition, superior axial resolution (1-5 µm) and generation of 3-dimensional images provides detailed measurements of RNFL and the macula4. [...]SD OCT permits segmentation and measurement of individual retinal layers using computer-assisted programs4. Subjects with media opacities precluding optimal image acquisition, anterior segment pathology, history of glaucoma, optic nerve or macular disease, family history of glaucoma and retinal dystrophies, previous history of ocular surgery or trauma, astigmatism >2.00 D, intraocular pressure (IOP) >21 mm Hg and cup/disc ratio >0.5 or asymmetry >0.2 were excluded from the study. Descriptive statistics i.e. mean ± standard deviation for quantitative values (age, axial length, RNFL thickness) and frequencies along with percentages for qualitative variables (gender, number of eyes) were used to describe the data. Kang SH, Hong SW, Im SK,...
ISSN:0030-9648
2411-8842