Synthesis and Structure–Activity Relationship Study of Novel Pyrazolylthiazoles as Potential Anti‐Breast Cancer Agents

A novel series of pyrazolylthiazole has been synthesized from the reaction of 5‐(4‐fluorophenyl)‐3‐aryl‐4,5‐dihydropyrazole‐1‐carbothioic acid amide derivatives with different reagents. The mechanism and structures of all the novel products were assured on the foundation of spectral information and...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2017-05, Vol.54 (3), p.1974-1982
Main Authors: Abbas, Eman M. H., Dawood, Dina H., Farghaly, Thoraya A., El‐hag, Fatma A., Ali, Mamdouh M.
Format: Article
Language:English
Subjects:
Breast cancer
Chemical synthesis
Line spectra
Reagents
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Summary:A novel series of pyrazolylthiazole has been synthesized from the reaction of 5‐(4‐fluorophenyl)‐3‐aryl‐4,5‐dihydropyrazole‐1‐carbothioic acid amide derivatives with different reagents. The mechanism and structures of all the novel products were assured on the foundation of spectral information and elemental analyses. The antitumor activity of all the synthesized compounds was estimated versus MCF‐7 cell line. The outcomes showed that some of the tested samples revealed powerful activity against human breast cancer cell line. In addition, the relation between the structure and the activity has been discussed.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2794