Evaluation of structural, mechanical, and cellular behavior of electrospun poly-3-hydroxybutyrate scaffolds loaded with glucosamine sulfate to develop cartilage tissue engineering

Considering the role of glucosamine sulfate (GS) in the biosynthetic pathways of chondrocytes, an attempt was made to design an electrospun poly-3-hydroxybutyrate (PHB) scaffold loaded with GS to develop cartilage tissue engineering. The study was initiated using the optimal electrospun scaffold con...

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Bibliographic Details
Published in:International journal of polymeric materials 2017-08, Vol.66 (12), p.589-602
Main Authors: Shahali, Zahra, Karbasi, Saeed, Avadi, Mohammad Reza, Semnani, Dariush, Naghash Zargar, Elham, HashemiBeni, Batoul
Format: Article
Language:English
Subjects:
Cartilage
Cartilage tissue engineering
Cell adhesion
Cell adhesion & migration
Cellular structure
chondrocyte
Electrospinning
electrospun scaffold
glucosamine sulfate
In vitro methods and tests
Kinetics
Mechanical properties
poly-3-hydroxybutyrate
Scaffolds
Spectrophotometry
Tissue engineering
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Summary:Considering the role of glucosamine sulfate (GS) in the biosynthetic pathways of chondrocytes, an attempt was made to design an electrospun poly-3-hydroxybutyrate (PHB) scaffold loaded with GS to develop cartilage tissue engineering. The study was initiated using the optimal electrospun scaffold conditions for the synthesis of PHB/GS. The resulting scaffolds have shown excellent pore architectures and mechanical behavior compared to pure PHB. UV spectrophotometric analysis, for the evaluation of the GS release behavior, showed zero-order kinetics release. In vitro results indicated excellent cell viability, cell adhesion, and cell penetration of PHB/GS scaffolds compared to pure PHB.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2016.1252353